charlielees's blog

Does physical inactivity lead to Crohn's disease? Will regular exercise improve outcomes in Crohn's disease?

The North American Nurses Health Study (2 cohorts initiated in 1976 and 1989 with 121.7k and 116.7k subjects respectively) is a very powerful tool to uncover disease aetiologies with minimal bias (especially recall bias). This has been applied successfully to Crohn’s disease and UC. In this study, where there is a massive 3.4 million person years of follow-up,  a total of 284 incident cases of Crohn’s disease and 363 incident cases of UC have been reported and verified. 

CCUK smartphone app for patients with Crohn's disease in Scotland

The BBC website reports on the CCUK funded smartphone app to help Crohn's patients monitor their symptoms and communicate with the IBD team. The app is being successfully piloted in the Highlands at present with plans for future development and roll-out across Scotland in place. Angus Watson is leading this exciting development. 

Insights into IBD aetiology from China …

…returning once again feeling energised, revitalised and inspired. This year I have visited Guangzhou, Shanghai and Xi’an. The Chinese people are amongst the friendliest and hospitable I have ever come across. The country offers endless fascinations from almost unbelievable historical sites with exquisite artefacts to traditions and cultures that are alive and strong. Witness the 6000 strong life-size terra-cotta army, built by thousands of men over 40 years to protect an emperor in the after-life, only to be buried underground and lain undiscovered for over 2000 years.

Biological insights arising from gene discovery in Crohn's disease : Paneth cells as a site of origin for intestinal inflammation.

The state-of-the art in IBD genetics is the immunochip experiment, a massive international collaborative effort involving over 70,000 individuals typed for nearly 200,000 SNPs (Jostins et al, Nature 2012,  To date, analysis of the I-chip by us and others has yielded a remarkable 193 independent risk variants in 163 susceptibility loci.

Use of mercaptopurine in azathioprine intolerant patients

Our paper on the clinical use of mercaptopurine in azathioprine intolerant patients has just been published on-line in Alimentary Pharmacology and Therapeutics (Kennedy NA, Rhatigan E, Arnott, IDR, Noble CL, Shand, AG, Satsangi J, Lees CW A trial of mercaptopurine is a safe strategy in patients with inflammatory bowel disease intolerant to azathioprine: an observational study, systematic review and meta-analysis).

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